Purine derivatives as inhibitors of PI3K - D, Methods for their preparation, Pharmaceutical formulations containing same and their use in the treatment of hyperproliferative Diseases
Methods of preparation and use of compounds for the treatment of cancer and other diseases: formula (1) or compounds of its stereoisomers, or mixtures of its stereoisomers, optionally as a pharmaceutically acceptable salt, wherein R1 is an optional pitch, halogen tar or cyclopentane Alternative； the remaining formula (2) is a ring of 4, 5, 6 or 7 members； wherein R2 in each substance is a halogenated, hydroxy, tar, alcoxi, hydroxy, hydroxy, halogenated alcoxi or - C (o) or - tar or two R2 groups can be combined with carbon to form a double ring on a bridge or fusion； n is 0, 1,When x is C or N； when x is n: R3 is not present； R3 rsqoe； is arilo or heterosexual, it can be replaced by one or two independent heterosexual groups； asphalt replaced by arilsulfonilamino； asphalt replaced by cyclomethylacrylonitrile； or R3 rsqoe； es-so2-ra, When x is C: R3 is cyanogen, carbamate, oxygen, carbonic acid or hydrogen Xi, R3 rsqoe； or R3 is hydrogen, R3 rsqoe； or when x is C,Substitution of 1-phenyl-4,5,6,7-tetrahydro-1h-pyrazol [3,4-c] pyridine, substitution of ILO, substitution of 1H benzo [D] [1.2,3] for triazole, substitution of oxoin, substitution of benzopyridine, substitution of pyridan, substitution of pyridine (substitution of furan)2-oxo-3, 4-dihydroquinonazolinilo, - C (o) nrbrc, wherein RB is hydrogen or tar； RC is an alternative alien； or R3 is hydrogen and R3 rsqoe； this is a formula group (a),(b)(c)(d)(e) Or (f),Among them, Z1 is O, NH or N, which can be selectively replaced by amino methanol, and a small number of tar or rsqoe can be leased； Z2 is ch or N； a is n-c-h or c-rd； each RD is a separate halogenated, tar, optional substitute or isopropyl substitute, re is amino or halogenated tar； or R3 and R3 rsqoe； They are combined with carbon to form an alternative ring, consisting of five to six formula members (g),(H)(I)(J)(K) (l)Among them, Z3 is CH2 or NH； Z4 is NRF or CRF, and RF is optional phenyl substitute； and there is no or halogen, asphalt, - (C = O
