REMY HALM,THEODOR STOLL,JEAN PLANCHER,SABINE MARC - KOLCZEWSKI,DELPHINE GAUFRETEAU
申请号：
ARP160103363
公开号：
AR106588A1
申请日:
2016.11.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
From indolin-2-ona These compounds can be used to treat harmful substances related to positive (psychosis) and negative symptoms such as schizophrenia, drug abuse, alcohol and drug abuse, obsessive-compulsive disorder, cognitive decline, bipolar disorder, emotional disorder, depression, drug-resistant depression. Treatment, anxiety, Alzheimer's disease, autism, Parkinson's disease, chronic pain, extreme personality disorder, neurodegenerative disease, sleep disorder, chronic fatigue syndrome, rigidity, inflammation, asthma, Huntington's disease, ADHD,Amebic lateral sclerosis, arthritis effects, autoimmune diseases, viral and fungal diseases, cardiovascular diseases, ophthalmic diseases and retinal inflammation as well as balance problems, epilepsy and neurodevelopmental disorders, and general epilepsy. 1. Characteristic 1: formula compound (1) with a as phenyl selected from formula group debris, or heteromorphic group (2) with 5 or 6 members and one or two N atoms；or the amide group -C (O) -NR¹R² can form together with two adjoining carbon atoms from group A an additional fused ring, selected from the residues of the group of formulas (3)；R1 / R2 is independent of each other, hydrogen, lower tar, lower tar replaced by halogen, lower tar replaced by hydroxyl group, (ch832222) c83322 low oxygen, oxetanil, cyclopentadiene, CH 832222lquilo, cyclopentadiene can be replaced by halogen, or R1 and R2 can be formed together with halogen； a. N atom (4) connected to the formula group；R3 is hydrogen or a lower tar, and a salt acceptable for a drug containing racemic mixtures or their counterpart counterpart counterpart counterpart counterpart and / or optical and / or stereoisomer.Derivados de indolin-2-ona. Los compuestos pueden usarse en el tratamiento de enfermedades del SNC relacionadas con síntomas positivos (psicosis) y negativos de la esquizofrenia, abuso de sustancias, alcohol y drogadicción, trastornos obsesivo-compulsivos, deterioro cognitivo, trastornos bipolares, tr
