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专利权人:
BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
ROSENSTEIN, BJRN,GEHRING, DORIS,DR. ALBUS, UDO,DR. BECK-BROICHSITTER, MORITZ,DR. NICOLAI, JANINE,LINDNER, NIELS,DR. COLLINS, KARL,DR. LUSTIG, KLEMENS,DR. MLLER, THOMAS,DR. HAHN, MICHAEL,DR. DELBECK, M
申请号:
ARP180101619
公开号:
AR112099A1
申请日:
2018.06.13
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. The present request relates to a pyrethroid derivative of pyrimidine [1,2-a] used as an alternative, its preparation procedures, procedures for use alone or in combination with those for the treatment and / or prevention of diseases, and the preparation of drugs for the treatment and / or prevention of diseases; In particular, treatment and / or prevention of respiratory disorders, including sleep related respiratory disorders, such as obstructive apnea and sleep and snoring central apnea. Claim 1: consists of formula (1),Where Q-ring is a non bicycle diaza selected from formula group (2),5. Takes note of the connection with the nearby Chr ö R group, * * takes note of the connection with the group; a is ch or N; R1 is halogen, cyanogen, c8321c83338324 tar, cyclopropene or cyclohexane, of which c8321c83183248324 tar can be replaced by fluorine and cyclohexane up to three times and fluorine up to two times; R2 is hydrogen or methyl; R3 is c833248331832683268cyclo, and one of the c8332222 ring groups can be - or -;O r 3 is a group of phenyl (3) in the formula,1. A group of pyridine (4) or (5) or a group of azol (6),it is life.**R83088 is hydrogen, fluorine, chlorine, bromine or methyl; r83099 is hydrogen, fluorine, chlorine, bromine, cyanogen, c8321833832323238a alcoxi, of which c832383232323232323 tar and c832183383232323238a alcoxi can be tripled; a. Fluorine, chlorine, bromine or methyl; r83117a means hydrogen, c83321218382323832323; 230xoxy can be replaced by fluorine up to three times; R831222 is hydrogen,a. Or S. O R3 is a group - or-83040;e. R1 ° is c8321833833183326a okiro, c8322431833218c8332626 cyclo or [c83233183326c18326 cycloquil] methyl; R1 ° is hydrogen or c83223233c83313b okiro; R1 ° is c8331833183318331833183326cqui ocquilo; c. C8321c833318331836262 tar can be replaced by fluorine up to three times, in which case, the phenyl and phenylphenyl groups can be replaced by a radical molecule selected from a group consisting of fluorine, chlorine, methyl,
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