TAO LI,SACHIN V. PATEL,RICHARD J. PERNER,JOHN T. RANDOLPH,MICHAEL R. SCHRIMPF,KEVIN R. WOLLER,ZHIREN XIA,QINGWEI ZHANG
申请号：
ARP120103574
公开号：
AR088064A1
申请日:
2012.09.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds including these compounds and salts； and (c) methods of using these compounds, salts, and compounds, particularly as calcium channel blockers. 1. Requirement 1: a compound (1) with formula characteristics,O salt, one is Z and Z, one is ch832222, the other is Z and Z, the other is ch8322o (o)；One of R1 and R2 is hydrogen, and one of R1 and R2 is g1-1 -；L es -C (R) (R) --C (o) No. 74919--No. 7491； - C (o)-S (O) NR --No. 7491； (s (o) 8322 -；- No. 7491stThat's it.G1 is apartment c83216c8318328a,Halogenated tar c83218c8331-8328；Ar1,- (CR R) -Ar-CH (Ar)or -Ar¹-Gᵃ；R749195 and r74955,In each case, they are c83218c833124248c tar independent of hydrogen,O halogenated tar c831832421；Rᶜ and Rᵈ are independently of each other hydrogen, hydroxy, C₁₋₄ alkyl,O halogenated tar c831832421；j is 1, 2, 3, 4 or 5； Ar¹ is, in each case, independently, aryl or heteroaryl, where Ar¹ is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C₁₋₄ alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；halogen, cyano, -NO₂,-Or738,-OC (O) R-OC (O) N (R) (R)-738；-S (O) R-S (O) R-S (O) N (R) (R)-C (O) R-C (O) OR-C (O) N (R) (R)-N (R) (R)-N (R) C (O) R-N (r738) C (o) or (r751111)；-N (R) S (O) (R)cyanoalkyl C₁₋₄,a. Halogenated tar c831832421；Rˢ and Rᵗ are, in each case, independently, hydrogen, C₁₋₄-alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；O halogenated tar c831832421；Gᵃ is cycloalkyl C₃₋₇,cycloalkenyl C₃₋₇,a. The bicycle c83231；cycloalkenyl C₃₋₇,a. Nonpositive cycle, or nonpositive cycle, or replace with 1, 2, or 3 c832183248f3；haloalkyl C₁₋₄,Or halogen； L2 es-s (o) 832222 -,-S (O) CH -That's it, that's it.G: c83217c83318328；Halogenated tar c83218c8331-8328；cycloalkyl C₁₋₈,Harp or harpAr² is aryl or heteroaryl, where Ar² is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of C₁₋₄ alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；halogen, cyano, -NO₂,-Or751222,-alkyl-ORᵘ,-OC (O) R-OC (O) N (R) (R)-751222,-S (O) R-S (
