LEE, HONG BOON,BURGESS, KEVIN,LIM, SIANG HUI,WU, LIANGXING
申请号：
EP09814826
公开号：
EP2331520A4
申请日:
2009.07.02
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a new class of rosamine derivatives, in one embodiment, the compounds have the structure (I) or any pharmaceutically acceptable salt or solvate thereof, wherein: R1 represents aryl, Het1 or C1-6 alkyl, which latter group is optionally substituted by aryl or Het2； R2a and R2b together form C3.8 n-alkylene, which alkylene group is optionally substituted by one or more substituents selected from halo, C1-4 alkyl, C(O)OH and C(O)O&mdash；C1-4, alkyl and which alkylene group is optionally interrupted by X1； R3a and R3b together form C3-6 /7-alkylene, which alkylene group is optionally substituted by one or more substituents selected from halo. C1-4 alkyl, C(O)OH and C(O)O&mdash；C1-4 alkyl, and which alkylene group is optionally interrupted by X2； X1 and X2 independently represent O, S, or NR4； R4 represents, independently at each occurrence, H, C(O)OR5, C(O)R6a, C(O)N(R6b)R6c or C1-6, alkyl, which latter group is optionally substituted by one or more substituents selected from halo, aryl and Het3 or is substituted by a single C(O)OR1a group； R4a represents H or C1-4 alkyl； R5 represents aryl, Het4 or C1-6 alkyl optionally substituted by one or more substituents selected from halo, aryl and Het5； R5e to R6d independently represent H or R5； each aryl independently represents a C6-10carbocylic aromatic group, which group may comprise either one or two rings and may be substituted by one or more substituents selected from halo, CN, C1-6 alkyl (which latter group is optionally substituted by one or more substituents selected from halo, OR7, phenyl, napthyl and Het6) and OR8； R7 and R8 independently represent H, C1-4 alkyl (optionally substituted by one or more halo groups or by a single phenyl or C(O)OR8a substituent), Het7, phenyl or naphthyl； R8a represents H or C1-4 alkyl； Het1 to Het7 independently represent 5- to 10-membered aromatic, fully saturated or partially unsaturated heterocyclic groups containing one or more heteroatoms selected f
