The invention relates to novel prodrugs or conjugates of the general formula (Ia)in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.本發明係關於通式(Ia)之新穎前藥或偶聯物其中細胞毒性藥劑(例如驅動蛋白紡錘體蛋白抑制劑)係經豆莢蛋白可裂解基團掩蔽且因此釋放該藥劑；且係關於該等前藥或偶聯物用於治療及/或預防疾病之用途，及該等前藥或偶聯物用於生產用於治療及/或預防疾病、尤其過度增殖及/或血管生成病症(例如癌症)之藥劑的用途。
