LERCHEN, Hans-Georg,REBSTOCK, Anne-Sophie,MARX, Leo,JOHANNES, Sarah Anna Liesa,STELTE-LUDWIG, Beatrix,DIETZ, Lisa,TERJUNG, Carsten,MAHLERT, Christoph,GREVEN, Simone,SOMMER, Anette,BERNDT, Sandra
申请号：
SG11201808167V
公开号：
SG11201808167VA
申请日:
2017.03.21
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS 5 The invention relates to novel prodrugs or conjugates of the general formula (Ia) (Ia) in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs 10 or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers. 15 No Suitable Figure
