Thomas E. Jenkins,Craig O. Husfeld,Julie D. Seroogy,Jonathan W. Wray
申请号：
US13708486
公开号：
US20130210854A1
申请日:
2012.12.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.
