JONATHAN W. WRAY,JULIE D. SEROOGY,THOMAS E. JENKINS
申请号：
BRPI0919711
公开号：
BRPI0919711A2
申请日:
2009.10.16
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
