Thomas E. Jenkins,Julie D. Seroogy,Jonathan W. Wray
申请号：
US14320351
公开号：
US09534014B2
申请日:
2014.06.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
