The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.本發明係關於具有改良性質之新穎結合劑-藥劑偶聯物(ADCs)、這些ADCs的活性代謝物及其製備方法。此外本發明係關於這些偶聯物用於治療和/或預防疾病的用途以及這些偶聯物用於製備治療和/或預防疾病，尤其是過度增生和/或血管生成的病症，例如癌症之藥品的用途。
