蕈毒鹼M2受體之正向異位調節劑农业专利-农业学术服务平台

发明人:: TELLER, HENRIK,特勒　亨里克,STRAUB, ALEXANDER,施特劳布　亚历山大,施特勞布　亞歷山大,BRECHMANN, MARKUS,布雷奇曼　马库斯,布雷奇曼　馬庫斯,MUELLER, THOMAS,米勒　汤玛士,米勒　湯瑪士,MEININGHAUS, MARK,迈宁豪斯　马克,邁寧豪斯　馬克,NOWAK-REPPEL, KATRIN,诺瓦克雷佩尔　卡特林,諾,特勒亨里克,施特劳布亚历山大,施特勞布亞歷山大,布雷奇曼马库斯,布雷奇曼馬庫斯,米勒汤玛士,米勒湯瑪士,迈宁豪斯马克,邁寧豪斯馬克,诺瓦克雷佩尔卡特林

摘要：: The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.本申請案關於蕈毒鹼M2受體之正向異位調節劑，尤其關於新穎的7-取代之1-芳基萘啶-3-甲醯胺，關於彼等的製備方法，關於彼等單獨或組合用於治療及/或預防疾病的用途，以及關於彼等用來製造用於治療及/或預防疾病，尤其用於治療及/或預防心血管病症及/或腎臟病症之醫藥品的用途。