The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.本申請案關於新穎的2,5-經雙取代之6-(三氟甲基)嘧啶-4(3H)-酮衍生物、關於彼等之製備方法、關於彼等單獨或合併用於治療及/或預防疾病的用途、以及關於彼等用於製備治療及/或預防疾病-尤其是治療及/或預防心血管、腎臟、發炎和纖維變性疾病-之醫藥品的用途。
