LÜCKING, Ulrich,BÖHNKE, Niels,SCHOLZ, Arne,LIENAU, Philip,SIEMEISTER, Gerhard,BÖMER, Ulf,KOSEMUND, Dirk,BOHLMANN, Rolf,ZORN, Ludwig
申请号：
ES13794844
公开号：
ES2622566T3
申请日:
2013.11.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the general formula (I) ** Formula ** in which R 1 represents a group selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, heterocyclyl, phenyl, heteroaryl, C 1 -C 3 alkyl or heteroaryl alkyl C1-C3-, wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group consisting of hydroxy, cyano, halogen, halo-C1-C3 alkyl-, C1- alkoxy C6-, C1-C3 fluoroalkoxy-, -NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, - OP (O) (OH) 2, -C (O) OH, -C (O) NH2； R2 represents a group selected from ** Formula ** R3, R4 independently represent each other, a group selected from a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, cyano, C1 alkyl -C3-, C1-C3 alkoxy-, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy-； R5 represents a group selected from a hydrogen atom, cyano, -C (O) R9, -C (O) OR9, -S (O) 2R9, - C (O) NR10R11, -P (O) (OR12) 2 , -CH2OP (OR12) 2, C1-C6 alkyl-, C3-C7- cycloalkyl, heterocyclyl-, phenyl, heteroaryl, wherein said C1-C6- alkyl group, C3-C7- cycloalkyl, heterocyclyl-, phenyl or heteroaryl is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3 alkyl-, C1-C3 alkoxy-, -NH2, alkylamino-, dialkylamino-, acetylamino-, N- methyl-N-acetylamino-, cyclic amines, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy； R6, R7 independently represent each other, a group selected from a hydrogen atom, a fluorine atom, a chlorine atom, C1-C3 alkyl-, C1-C3 alkoxy-, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy； R8 represents a group selected from a) a C1-C6 alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, hydroxy, -NH2, alkylamino-, dialkylamino-, acetylamino- , Nmethyl- N-acetylamino-, cyclic amines, cyano, C1-C3 alkyl-, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy-, C1-C3- alkoxy, C2-C3 alkenyl, C2-C3 alkynyl- , C3-C7- c
