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Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximin group
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
KOSEMUND, Dirk,LÜCKING, Ulrich,SIEMEISTER, Gerhard,SCHOLZ, Arne,LIENAU, Philip
申请号:
ES15778981
公开号:
ES2691227T3
申请日:
2015.10.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I) ** Formula ** in which R1 represents a group selected from C1-C6 alkyl, C3-C7 cycloalkyl, heterocyclyl, phenyl, heteroaryl, C1-C3 phenylalkyl and C1-C3 heteroaryl-alkyl, wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of hydroxy, cyano, halogen, C1-C3 haloalkyl, C1-C6 alkoxy, C1-C3 fluoroalkoxy, -NH2 , alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, -OP (O) (OH) 2, - C (O) OH, -C (O) NH2; R2 represents the group ** Formula ** R3, R4 represents, independently of each other, a group selected from a hydrogen atom, fluorine atom, chlorine atom, bromine atom, cyano, -SF5, C1-C3 alkyl , C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 fluoroalkoxy; R5 represents a group selected from a hydrogen atom, cyano, -C (O) R9, -C (O) OR9, -S (O) 2R9, - C (O) NR10R11, -P (O) (OR12) 2 , -CH2OP (OR12) 2, C1-C6 alkyl, C3-C7 cycloalkyl, heterocyclyl, phenyl, heteroaryl, wherein said C1-C6 alkyl-, C3-C7 cycloalkyl, heterocyclyl, a phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3 alkyl, C1-C3 alkoxy, -NH2, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines , C1-C3 haloalkyl, C1-C3 fluoroalkoxy; R6, R7 represent, independently of one another, a group selected from a hydrogen atom, fluorine atom, chlorine atom, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 fluoroalkoxy; R8a, R8b represent, independently of each other, a group selected from a hydrogen atom, fluorine atom, chlorine atom, bromine atom, cyano, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, fluoroalkoxy C1-C3; R9 represents a group selected from C1-C6 alkyl, C1-C3 haloalkyl, C3-C7 cycloalkyl, heterocyclyl, phenyl, benzyl and heteroaryl, wherein said group is optionally substituted with one, two or three substituents, identically or differently , select
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