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Substituted 5-fluoro-pyrimidine derivatives containing a sulfoximin group
专利权人:
Bayer Intellectual Property GmbH
发明人:
LÜCKING, Ulrich,KOSEMUND, Dirk,SCHOLZ, Arne,LIENAU, Philip,SIEMEISTER, Gerhard,BÖMER, Ulf,BOHLMANN, Rolf
申请号:
ES12758496
公开号:
ES2588102T3
申请日:
2012.09.13
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of general formula (I) ** Formula ** in which R1 represents a group selected from C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl, phenylalkyl-C3-alkyl or heteroaryl-alkyl C1-C3-, wherein said group is optionally substituted with one or two or three substituents, selected identically or differently from the group of hydroxy, cyano, halogen, halo-C1-C3-alkyl, C1-C6-alkoxy- , fluoroalkoxy C1-C3-, amino, alkylamino-, dialkylamio-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines; R2 represents a group selected from ** Formula ** R3, R4 represent, independently of one another, a group selected from a hydrogen atom, a halogen atom, cyano, -SF5, C1-C3-alkyl, C1- alkoxy C3-, halo-C1-C3alkyl-, fluoroalkoxy C1-C3-; R5 represents a group selected from a hydrogen atom, cyano, -C (O) R9, -C (O) OR9, -S (O) 2R9, -C (O) NR10R11, C1-C6-alkyl, C3-cycloalkyl- C7-, heterocyclyl-, phenyl, heteroaryl, wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three selected substituents, in the same or different form , between halogen, hydroxy, cyano, C1-C3-alkyl, C1-C3-alkoxy, amino, alkylamino-, dialkylamio-, acetylamino-, N-methyl-N20-acetylamino-, cyclic amines, halo-C1-C3-alkyl, fluoroalkoxy C1-C3-; R6, R7 represent, independently of one another, a group selected from a hydrogen atom, a halogen atom, cyano, C1-C3-alkyl, C1-C3-alkoxy, halo-C1-C3-alkyl, fluoro-C1-alkyl. C3-; R8 represents a group selected from a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, selected identically or differently from the group of halogen, hydroxy, amino, alkylamino-, dialkylamium-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3alkyl-, halo-C1-C3alkyl-, fluoroalkoxy C1-C3-, alkoxyC2-C3-, alkynyl C2-C3-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl, wherein said C3-C7-, heterocyclyl-, phenyl or heteroaryl cycloalkyl group is opt
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