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4- (Ortho) -fluorophenyl-5-fluoropyrimidin-2-ylamines containing a sulfoximin group
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
LÜCKING, Ulrich,KOSEMUND, Dirk,BOHLMANN, Rolf,SCHOLZ, Arne,LIENAU, Philip,SIEMEISTER, Gerhard,BÖMER, Ulf
申请号:
ES13794840
公开号:
ES2622583T3
申请日:
2013.11.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of general formula (I) ** Formula ** in which R 1 represents a group selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, heterocyclyl, phenyl, heteroaryl, C 1 -C 3 -phenyl alkyl or heteroaryl-C 1 alkyl -C3-, wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected from the group consisting of hydroxy, cyano, halogen, halo-C1-C3 alkyl-, C1- alkoxy C6-, C1-C3 fluoroalkoxy-, -NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-Nacethylamino-, cyclic amines, -OP (O) (OH) 2, -C (O) OH, -C (O) NH2; R2 represents the group ** Formula ** R3, R4 independently represent each other, a group selected from a hydrogen atom, halogen atom, cyano, -SF5, C1-C3 alkyl-, C1-C3 alkoxy-, hydroxy, halo-C1-C3 alkyl, C1-C3 fluoroalkoxy; R5 represents a group selected from a hydrogen atom, cyano, -C (O) R8, -C (O) OR8, -S (O) 2R8, - C (O) NR9R10, -P (O) (OR11) 2 , -CH2OP (OR11) 2, C1-C6 alkyl-, C3-C7- cycloalkyl, heterocyclyl-, phenyl, heteroaryl, wherein said C1-C6 alkyl-, C3-C7- cycloalkyl-, heterocyclyl-, phenyl or heteroaryl is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3 alkyl-, C1-C3 alkoxy-, -NH2, alkylamino, dialkylamino, acetylamino, N-methyl -N-acetylamino, cyclic amines, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy; R6, R7 independently represent each other, a group selected from a hydrogen atom, fluorine atom, chlorine atom, C1-C3 alkyl, C1-C3 alkoxy, halo C1-C3 alkyl, C1 fluoroalkoxy -C3-; R8 represents a group selected from C1-C6- alkyl, C3-C7- cycloalkyl, heterocyclyl-, phenyl, benzyl or heteroaryl, wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected among halogen, hydroxy, C1-C3- alkyl, C1-C3- alkoxy, -NH2, alkylamino, dialkylamino, acetylamino, N-methyl-N-acetylamino, cyclic amines, halo-C1-C3 alkyl-, C1-C3 fluoroalkoxy ; R9, R10 independently represent ea
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