KUNOS GEORGE,IYER MALLIGA,CINAR RESAT,RICE KENNER C
申请号：
IN201637038171
公开号：
IN201637038171A
申请日:
2016.11.08
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
12 32 32a 1bThe application relates to cannabinoid receptor mediators or a pharmaceutically acceptable salt or ester thereof useful in the treatment of e.g. obesity diabetes or gout having a structure of: Formula I or Formula I wherein X and Y are each independently selected from optionally substituted aryl optionally substituted heteroaryl optionally substituted cycloalkyl optionally substituted heterocycloalkyl or optionally substituted alkyl Q is H hydroxyl or optionally substituted alkoxy R R and R are each independently selected from H optionally substituted alkyl optionally substituted cycloalkyl halogen cyano nitro hydroxy optionally substituted alkoxy amino aminocarbonyl optionally substituted sulfonyl optionally substituted aryl optionally substituted heteroaryl optionally substituted carboxyl acyl optionally substituted alkenyl optionally substituted alkynyl optionally substituted phosphonyl optionally substituted phosphinyl aralkyl optionally substituted thiol or Rand R together with Z form an optionally substituted cycloalkyl ring or an optionally substituted heterocycloalkyl ring Z is B N CH or P D is S(O) or C(O) and n is 0 to 5. The application also relates to compounds of Formula II wherein U is Formula (A) wherein Ris C( =NH)R and R is a substituted sulfonyl or a substituted carbonyl.
