АКИРЕДДИ Сриниваса Рао (US),БРЕЙНИНГ Скотт Р. (US),МЕЛВИН Мэтт С. (US),МЕРТИ Сриниваса В. (US),МАЗУРОВ Анатолий А. (US),БХАТТИ Балвиндер Сингх (US),СТРАХАН Джон-Пол (US),ХИМСТРА Рональд Джозеф (US),ШО
申请号：
RU2013136851/04
公开号：
RU2013136851A
申请日:
2012.01.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound of formula I: Formula I, wherein each of R and R is independently H, C-alkyl, or R and R, in combination with the nitrogen atom to which they are attached, form a 3-8 membered ring, said ring optionally substituted； each of R and R independently means H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； R is H or C-alkyl； each of X, X, X and X is independently - (CRR) -, where each of R and R independently are H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； or a pharmaceutically acceptable salt thereof. 2. The compound of formula II: Formula II, where each of R and R is independently H, C-alkyl, or R and R, in combination with the nitrogen atom to which they are attached, form a 3-8 membered ring, said ring being optionally substituted； each of R R independently is H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； R is H or C-alkyl； each of X, X and X is independently - (CRR) -, where each of R and R is independently H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； or a pharmaceutically acceptable salt thereof. 3. A compound of formula III: Formula III, wherein each of R and R is independently H, C-alkyl, or R and R, in combination with the nitrogen atom to which they are attached, form a 3-8 membered ring, said ring being optionally substituted； each of R R independently is H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； R is H or C-alkyl； each of X, X, X, X and X is independently - (CRR) -, where each of R and R independently are H, halogen, C-alkyl, C-haloalkyl, hydroxyl, C-alkoxy or C-aryloxy； or a pharmaceutically acceptable salt thereof. 4. The compound according to claim 1, where optional1. Соединение формулы I:Формула I,где каждый из Rи Rнезависимо означает H, C-алкил, или Rи Rв комбинации с атомом азота, к которому присоединены, образуют 3-8-членный цикл, причем указанный цикл может быть необязательно замещенным；каждый из Rи Rнезависимо означает H, галоген
