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5-羥基嘧啶-4-羧醯胺衍生物
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
KURIBAYASHI, TAKESHI,栗林健,KUBOTA, HIDEKI,洼田秀树,窪田秀樹,TANAKA, NAOKI,田中直树,田中直樹,FUKUDA, TAKESHI,福田刚,福田剛,TSUJI, TAKASHI,辻贵司,辻貴司,GOTO, RIKI,後藤力
申请号:
TW099135723
公开号:
TWI469975B
申请日:
2010.10.20
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention provides a compound represented by general formula (1) or a pharmacologically acceptable esters thereof or a pharmacologically acceptable salts thereof, which is capable of promoting the production of erythropoietin.[In formula (1), R1represents a group represented by formula (1A)[In formula (1A), R4, R5represent a hydrogen atom, a halogen atom, an alkyl group; R6represents a hydrogen atom, a halogen atom, an alkyl group or the like; R7represents an optionally substituted hydroxyalkyl group, an optionally substituted hydroxyhalogenoalkyl group, an optionally substituted alkoxyalkyl group or the like; and the substituent group α represents an oxo group, a hydroxy group, an amino group or the like; ring Q1represents a monocyclic heterocyclic group; ring Q2represents a monocyclic hydrocarbon ring group, a monocyclic heterocyclic group; ring Q3represents a monocyclic hydrocarbon ring group, a monocyclic heterocyclic group; X represents a single bond, a methylene group, an ethylene group or the like]; R2represents an alkyl group, a methylsulfanyl group; and R3represents a hydrogen atom, a methyl group].本發明提供一種增強紅血球生成素產生之化合物,其係以式(1)所代表之化合物等:[在式(1)中,R1:式(1A)[式(1A)中,R4、R5:H、鹵素、烷基;R6:H、鹵素、烷基等;R7:可經取代之羥基烷基、可經取代之羥基鹵烷基、可經取代之烷氧基烷基等;取代基群α:側氧基、羥基、胺基等;環Q1:單環之雜環基;環Q2:單環之烴環基、單環之雜環基;環Q3:單環之烴環基、單環之雜環基;X:單鍵、亞甲基、伸乙基等];R2:烷基、甲基硫烷基;R3:H、甲基]。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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