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Modulators of the azadecalin glucocorticoid receptor condensed with heteroaryl ketone
专利权人:
Corcept Therapeutics; Inc.
发明人:
HUNT, Hazel,JOHNSON, Tony,RAY, Nicholas,WALTERS, Iain
申请号:
ES13793417
公开号:
ES2665338T3
申请日:
2013.05.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound having the formula: ** (See formula) ** in which R1 is a heteroaryl ring having 5 to 6 ring members and 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-4 groups each independently selected from R1a; each R1a is independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, -CN, N-oxide, C3-8 cycloalkyl and C3- heterocycloalkyl 8; the J ring is selected from the group consisting of a cycloalkyl ring, a heterocycloalkyl ring, an aryl ring and a heteroaryl ring, in which the heterocycloalkyl and heteroaryl rings have 5 to 6 ring members and 1 to 4 heteroatoms each one independently selected from the group consisting of N, O and S; each R2 is independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkyl-C1-6 alkoxy, -CN, -OH, -NR2aR2b, -C (O) R2a, -C (O) OR2a, -C (O) NR2aR2b, -SR2a, -S (O) R2a, -S (O) 2R2a, C3-8 cycloalkyl and C3-8 heterocycloalkyl , wherein the heterocycloalkyl groups are optionally substituted with 1-4 R2c groups; alternatively, two R2 groups attached to the same carbon combine to form an oxo group (>; = O); alternatively, two R2 groups combine to form a heterocycloalkyl ring having 5 to 6 ring members and 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, in which the heterocycloalkyl ring is optionally substituted with 1 to 3 R2d groups; each of R2a and R2b is independently selected from the group consisting of hydrogen and C1-6 alkyl; each R2c is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, -CN and -NR2aR2b; each R2d is independently selected from the group consisting of hydrogen and C1-6 alkyl, or two R2d groups attached to the same ring atom combine to form (>; = O); R3 is selected from the group consisting of phenyl and
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