The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
KUNOS, George,IYER, Malliga,CINAR, Resat,RICE, Kenner C.
申请号：
AU2019227889
公开号：
AU2019227889A1
申请日:
2019.09.10
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019227889A120190926.pdf#####ABSTRACT The application relates to cannabinoid receptor mediators, or a pharmaceutically acceptable salt or ester thereof, useful in the treatment of e.g. obesity, diabetes or gout, having a structure of: wherein X and Y are each independently selected from optionally- substituted aryl, optionallysubsti-tuted heteroaryl, optionally- substituted cycloalkyl, optionally-substituted heterocycloalkyl, or optionally-substituted alkyl； • Q is H, hydroxyl, or optionally-substituted alkoxy； • R, R2 , and R3 are each independently selected from H, optionally-substituted alkyl, optionally-substituted cycloalkyl, halogen, cy-ano, nitro, hydroxy, optionally-substituted alkoxy, amino, aminocarbonyl, optionally-substituted sulfonyl, optionally- substituted aryl, optionally-substituted heteroaryl, optionally- substituted carboxyl, acyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted phosphonyl, optionallysubstituted phosphinyl, aralkyl, optionally-substituted thiol, or R2 and R3 together with Z form an optionally-substituted cycloalkyl ring or an optionally-substituted heterocycloalkyl ring； • Z is B, N, -CH-, or P； • D is -S(O) 2- or -C(O)-； and • n is 0 to 5. The application also relates to compounds of Formula II wherein Ra is -C(=NH)R； and Rb is a substituted sulfonyl or a substituted carbonyl.
