MISTRELLO, GIOVANNI,RONCAROLO, DANIELA,ZANONI, DARIO,ZANOTTA, STEFANIA,FALAGIANI, PAOLO
申请号：
ES09748476
公开号：
ES2384680T3
申请日:
2009.10.02
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Modified allergens that have reduced allergenicity compared to the corresponding natural allergenic material, and characterized in that all or a part of the primary amine groups of the lysine and arginine residues of the allergenic molecules are functionalized as shown in structure (I), and because said Modified allergens have the following structure (I): in which: R and R2 are independently selected from H, C1-C5 alkyl, phenyl, optionally substituted in ortho, meta or paracon a hydroxy group, C1-C4 alkoxy, halogen, amino, alkylamino, dialkylamino, mercapto, C1-C4 alkylmercapto； X represents O, S or NR3, wherein R3 is H, alkyl with 1-6 carbon atoms, phenyl or CN； R1 represents H, alkyl with 1-8 atoms of carbon, phenyl or arylalkyl with up to 8 carbon atoms, or alkyl containing a heterocyclic ring； prot represents the rest of the allergen protein； n is the number of functionalized arginine groups, and is in the range between 1 and the number of arginine groups present in the allergen； m is the number of functionalized lysine groups and is in the range between 1 and the number of lysine groups present in the allergen.Alérgenos modificados que tienen alergenicidad reducida comparado con el correspondiente material alergéniconatural, y caracterizados porque todos o una parte de los grupos amina primaria de los restos de lisina y arginina delas moléculas alergénicas se funcionalizan como se muestra en la estructura (I), y porque dichos alérgenosmodificados tienen la siguiente estructura (I):en la que:R y R2 se seleccionan independientemente de H, alquilo C1-C5, fenilo, opcionalmente sustituido en orto, meta o paracon un grupo hidroxi, alcoxi C1-C4, halógeno, amino, alquilamino, dialquilamino, mercapto, alquilmercapto C1-C4；X representa O, S o NR3, en el que R3 es H, alquilo con 1-6 átomos de carbono, fenilo o CN；R1 representa H, alquilo con 1-8 átomos de carbono, fenilo o arilalquilo con hasta 8 átomos de carbono, o alquiloque contiene un anillo heterocíclico；prot repres
