LASSALLE GILBERT,MARTIN VALERIE,VOLLE CHALLIER CECILE,MCCORT GARY
申请号：
CO12084563
公开号：
CO6481011A2
申请日:
2012.05.23
申请国别(地区):
CO
年份:
2012
代理人:
摘要：
The Invention relates to Derivatives of (R) - piridinonas piridino that respond to the formula (i), wherein R1 represents a hydrogen Atom or an alkyl group (C1 - C4)； R2 represents a Group - n '- (CH2) (where n = 0, 1, 2, 3 or 4 and B represents a cycloalkyl Group (c3-c5), an alkyl group (C1 - C4 ) or an alkoxy Group (C1 - C4)； y, Z, and W represent, independently, a Group - ch -A carbon Atom, Atom Atom or a lack of understanding that the Cycle, including V, W, y, and Z is a cycle comprising 5 or 6 links, while dashed lines indicate that the cycle in the cycle is a cycle and entendi u00e9 Aromatic With this cycle includes 0, 1 or 2 heteroatoms； R3 and R4 represent, independently,Identical or different groups selected from a hydrogen Atom, an alkyl group (C1 - C4) or linear form along with the carbon to which are attached a cycloalkyl Group (c3-c5)； M is an integer equal to 1, 2, 3 or 4； R5 represents a hydrogen Atom or a alkyl group (C1 - C4)； R6 Represents a Group - (CH2) n - l in which n = 0, 1, 2 or 3,And l is a selected Group among arils of 6 carbon ATOMS, heteroaryl 5 or 6 links, saturated Heterocycles containing 5, 6 or 7 links or Form along with the nitrogen Atom to which are attached a heterocycle Group.(ii) and (iii) to prepare your application in Therapeutics as inhibitors of the kinase activity of receptors / ligands or receptors pdgfs and FLT3 ligand.La invención se refiere (i) a derivados de piridino-piridinonas que responden a la fórmula (I) : en la que R1 representa un átomo de hidrógeno o un grupo alquilo(C1-C4)； R2 representa un grupo -(CH2)n'-B donde n'=0, 1, 2, 3 o 4 y B representa un grupo cicloalquilo(C3-C5), un grupo alquilo(C1-C4) o un grupo alcoxi(C1-C4)； Y, Z, Y y W representan, independientemente entre sí un grupo -CH-, un átomo de carbono, un heteroátomo o ausencia de átomo, entendiéndose que el ciclo, en el que están comprendidos V, W, Y y Z es un ciclo que comprende 5 o 6 eslabones, entendiéndose que las líneas discontinuas en dicho cic
