GARY MCCORT,VALERIE MARTIN,GILBERT LASALLE,CECILLE VOLLE-CHALLIER
申请号：
MX2012005988
公开号：
MX2012005988A
申请日:
2010.11.22
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The invention relates (i) to pyridine-pyridinone derivatives with the formula (I): where R1 is a hydrogen atom or a (C1-C4)alkyl group； R2 is a (CH2)n-B group, in which n' = 0, 1, 2, 3 or 4 and B is a (C3-C5)cycloalkyl group, a (C1-C4)alkyl group or a (C1-C4)alkoxy group； Y, Z, V and W are, independently from one another, a -CH- group, a carbon atom, a heteroatom or no atom, with the understanding that the cycle, which includes V, W, Y and Z, is a cycle including 5 or 6 members, with the understanding that the dotted lines in said cycle indicate that the resulting cycle is an aromatic cycle and with the understanding that said cycle includes 0, 1 or 2 heteroatoms； R3 and R4 are, independently from one another, identical or different groups selected among a hydrogen atom and a straight (C1-C4)alkyl group, or form a (C3-C5)cycloalkyl group together with the carbon to which the former are bonded； m is an integer equal to 1, 2, 3 or 4； R5 is a hydrogen atom or a (C1-C4)alkyl group； R6 is a (CH2)n-L group where n = 0, 1, 2 or 3, and L is a group selected among aryls with 6 carbon atoms, heteroaryls having 5 or 6 members, the saturated heterocycles including 5, 6 or 7 members or forming a heterocycle group together with the nitrogen atom to which the former are linked. The invention also relates (ii) to the preparation of said derivatives, and (iii) to the therapeutic use thereof as inhibitors of kinase activity in receptors having PDGF ligands and/or receptors with the FLT3 ligand.La invención se refiere (i) a derivados de piridino-piridinonas que responden a la fórmula (I): en la que R1 representa un átomo de hidrógeno o un grupo alquilo(C1- C4)； R2 representa un grupo -(CH2)n-B donde n'=O, 1, 2, 3 o 4 y 8 representa un grupo cicloalquilo(C3-C5), un grupo alquilo(C1-C4) o un grupo alcoxi(C1-C4) ； Y, Z, V y W representan, independientemente entre sí un grupo -CH-, un átomo de carbono, un heteroátomo o ausencia de átomo, entendiéndose que el ciclo, en el que están compr
