NOVEL INTRA-ARTICULAR CATIONIC LIPOSOMAL FORMULATION OF SOME ANTI-ARTHRITIC AGENTS WITH IMPROVED DRUG RESIDENCE TIME AND THE PROCESS OF THEIR PREPARATION
The present invention provides novel intra-articular cationic liposomal formulation of non-steroidal anti-inflammatory agents (NSAID) such as 6-methoxy-2-naphthylacetic acid, biphenylacetic acid, naproxen and their salts having positive zeta potential for the prevention and/or treatment of inflammatory and/or autoimmune disorders or associated conditions. The resulting formulations to be injected locally into the joint spaces where it will adhere to local tissues by ionic interaction (cationic lipid) to provide sustained release of NSAID from liposomes and elicit therapeutic effect of NSAID over long duration. These pharmaceutical formulations exhibit local anti-inflammatory activities when administered and provide therapeutic effect over long duration with improved drug residence time in joint cavity for the prevention and/or treatment of inflammatory and/or autoimmune disorders or associated conditions.
