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Process for preparing granular compositions
专利权人:
Reckitt Benckiser Healthcare (UK) Limited
发明人:
申请号:
EP10158751.7
公开号:
EP2198856B1
申请日:
2002.05.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A process for the preparation of a granular composition comprising solidified melt granules comprising a non-steroidal anti-inflammatory drug (NSAID) as a continuous phase, which process comprising the steps of: (a) melt-extruding the NSAID, optionally with excipients; (b) forming a homogeneous extrudate; (c) cooling the extrudate; and (d) comminuting the cooled extrudate to form granules; characterised in that in the step (a) the NSAID is fully melted and that in step (b) the extrudate is formed into two or more ribbons having a depth of 10 mm or less and which solidify in 5 minutes or less.
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