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CRISTAL DE (S)-1-(2-HYDROXYETHYLE)-4-METHYLE-N-[4-(METHYLESULFONYL)PHENYL]-5-[2-(TRIFLUOROMETHYLE)PHENYLE]-LH-PYRROLE-3-CARBOXAMIDE
专利权人:
Limited;Daiichi Sankyo Company
发明人:
申请号:
EP17157692.9
公开号:
EP3190102B1
申请日:
2014.04.07
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)pheny l]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.
来源网站:
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来源网址:
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