The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)pheny l]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.本發明之課題係提供具有優異的礦物皮質素(mineral corticoid)受體拮抗作用的吡咯衍生物之阻轉異構物(atropisomer)之製造中間體、製造方法及其結晶。一種吡咯衍生物之阻轉異構物之製造方法及(S)-1-(2-羥基乙基)-4-甲基-N-[4-(甲基磺醯基)苯基]-5-[2-(三氟甲基)苯基]-1H-吡咯-3-甲醯胺之結晶，該方法係包含分割下述通式(I)之阻轉異構物的步驟，其特徵為使用具有脫氧辛可寧(cinchonane)骨架的光學活性胺，[式中，R1表示甲基或三氟甲基，R2表示氫原子或C1-C3烷氧基，n表示選自1~3的整數]。
