PHARMACEUTICAL COMPOSITION COMPRISING NOVEL HYDROXAMIC ACID DERIVATIVE OR SALT THEREOF农业专利-农业学术服务平台

发明人:: HONDA, TATSUYA,本多达也,本多達也,SUZUMURA, YUKO,铃村佑子,鈴村祐子,KATO, TOMOYA,加藤智也,加藤智也,KOSEKI, YU,古关优,古關優,ONO, KOHEI,小野耕平,小野耕平,SHOJI, MUNEO,庄司宗生,庄司宗生,SUGAYA, NAOMI,菅谷直未,菅谷直未,TANAKA, NAOKO,田中直子,田中直子

摘要：: A pharmaceutical composition comprising a hydroxamic acid derivative selected from (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N, 2-dimethylmalonamide, (2S)-2-((4-((4-((1R)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N, 2-dimethymalonamide and (2S)-N-hydroxy-2-((4-((4-((1S)-1-hydroxy-2-methoxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N, 2-dimethylmalonaniide, or a salt thereof, and a solubilizing agent exhibits potent antimicrobial activity, has excellent water solubility, and is useful as a medicine.一種含有選自(2S)-2-((4-((4-((1S)-1,2-二羥乙基)苯基)乙炔基)苯甲醯基)(甲基)胺基)-N-羥基-N’,2-二甲基丙二醯胺、(2S)-2-((4-((4-((1R)-1,2-二羥乙基)苯基)乙炔基)苯甲醯基)(甲基)胺基)-N-羥基-N’,2-二甲基丙二醯胺、及(2S)-N-羥基-2-((4-((4-((1S)-1-羥基-2-甲氧基乙基)苯基)乙炔基)苯甲醯基)(甲基)胺基)-N’,2-二甲基丙二醯胺之異羥肟酸(hydroxamic acid)衍生物或其鹽以及助溶劑之醫藥組成物,其顯示強抗菌活性,且對水之溶解性優異,作為醫藥為有用。