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二吡咯亞甲基的結晶及其製備方法
专利权人:
Daiichi Sankyo Company Limited
发明人:
WATANABE, Masashi,OKACHI, Takahiro,KAWAHARA, Michiaki,NAGASAWA, Hiroshi,SATO, Noritada,TAKITA, Takashi,HASEGAWA, Gen,渡邊 仁,岡地 隆弘,川原 倫明,長澤 大史,佐藤 仙忠,瀧田 崇,長谷川 玄
申请号:
HK16109149.3
公开号:
HK1221214A
申请日:
2016.08.01
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
The present invention provides a production intermediate of an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, a method for producing the same, and a crystal thereof. A method for producing an atropisomer of a pyrrole derivative including a step of resolving a compound represented by the following general formula (I) [wherein R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C1-C3 alkoxy group, and n represents an integer selected from 1 to 3] into its atropisomers, characterized by using an optically active amine having a cinchonine skeletal formula, and a crystal of (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)pheny l]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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