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CRYSTAL OF PYRROLE DERIVATIVE AND METHOD FOR PRODUCING THE SAME
专利权人:
发明人:
申请号:
HK18100373.7
公开号:
HK1241358A
申请日:
2016.08.01
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
The present invention provides a production interrnediateof an atropisomer of a pyrrole derivative having excellentmineralocorticoid receptor antagonistic activity, a methodfor producing the same, and a crystal thereof. A method forproducing an atropisomer of a pyrrole derivative including astep of resolving a compound represented by the followinggeneral formula (I) [wherein R1 represents a methyl group ora trifluoromethyl group, R2 represents a hydrogen atom or aC1-C3 alkoxy group, and n represents an integer selected from1 to 3] into its atropisomers, characterized by using anoptically active amine having a cinchonine skeletal formula,and a crystal of(S) -1- (2-hydroxyethyl) -4-methyl-N- [4- (methylsulfonyl)pheny1] -5- [2- (trifluoromethyl) phenyl] -1H-pyrrole-3-carboxamide.(See Formula I)
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