The invention relates to a compound of formula I,Where y is c-r1 '；R1 'is hydrogenF or Cl；R1 is f or CL；R2 is hydrogen or lower alkyl group；R3 is phenylPyridine or isothiazolyl,The N atom in the pyridine group can be in different positions,Selectively replaced by one or more halogen atoms；R4 is hydrogen or lower alkyl group；Het is a 5-membered heteroaryl group,It contains two or three selected from nThe heteroatom of O or s,It is selectively substituted by a lower alkyl groupCycloalkanesLow alkoxyalkylThe heteroatom is a heterocyclic alkyl group of O or a lower alkyl substituted by a hydroxyl group,Or bicyclic heteroaromatic rings,It contains two or three n-heteroatoms,Selected from group (II)(III)、(4) Or (V)；Or related to its medicinal salt or acid addition salt,Involving racemic mixtures,Or related to their corresponding enantiomers and / or optical isomers and / or stereoisomers.The compounds can be used in the treatment of Parkinson's disease, anxiety, vomiting, obsessive-compulsive disorder, autism, neuroprotection, cancer, depression and type 2 diabetes.本發明涉及式I的化合物，其中Y是C-R1’；R1’是氫、F或Cl；R1是F或Cl；R2是氫或低級烷基；R3是苯基、吡啶基或異噻唑基，其中所述吡啶基中的N原子可以在不同位置，任選地被一個或多個鹵素原子取代；R4是氫或低級烷基；Het是5元雜芳基，其含有兩個或三個選自N、O或S的雜原子，任選地被低級烷基、環烷基、低級烷氧基烷基、其中雜原子是O的雜環烷基或被羥基取代的低級烷基取代，或者是二環雜芳環，其含有兩個或三個N-雜原子，選自基團(II)、(III)、(IV)或(V)；或者涉及其藥用鹽或酸加成鹽，涉及外消旋混合物，或涉及其相應的對映異構體和／或旋光異構體和／或立體異構體。所述化合物可以用於治療帕金森病、焦慮、嘔吐、強迫症、自閉症、神經保護、癌症、抑鬱症和2型糖尿病。
