The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl； R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino； R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo； Z is NH, N-alkyl, or O； R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo； and n is 0 or 1. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.本發明係關於式I化合物：其中環A為苯基(phenyl)、萘基(naphthalenyl)、吡啶基(pyridyl)、喹啉基(quinolinyl)、異喹啉基(isoquinolinyl)、咪唑并吡啶基(imidazopyridyl)、呋喃基(furanyl)、噻唑基(thiazolyl)、異唑基(isoxazolyl)、吡唑基(pyrazolyl)、咪唑并噻唑基(imidazothiazolyl)、苯并咪唑基(benzimidazolyl)或吲唑基(indazolyl)；R1為H、烷基、烷氧基、羥基伸烷基、OH、鹵基、苯基、三唑基、唑基、異唑基、吡啶基、嘧啶基、吡基、嗒基、哌基、吡唑基、二唑基、吡咯啶基、苯硫基、嗎福啉基或二烷基胺基；R2為H、烷基、烷氧基、羥基伸烷基或鹵基；Z為NH、N-烷基或O；R5為吡啶基、嘧啶基、吡基、嗒基、喹唑啉基、喹啉基、吡唑基、苯并唑基、咪唑并吡基、三唑并吡基，選擇地經一或兩個獨立選自由烷基、烷氧基及鹵基所組成之群組的取代基取代；以及n為0或1。亦說明製造式I化合物之方法。本發明亦關於包含式I化合物之醫藥組成物。本發明化合物之使用方法亦屬於本發明之範疇。
