The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ[Formula 15]€ƒ€ƒ€ƒ€ƒ€ƒA-Y [1] wherein A represents a structure represented by the following formula [2]: wherein R 11 and R 12 each represent a halogen atom or the like, R 2 represents C 1-6 alkyl or the like, ring E represents triazole, tetrazole, pyrimidine, or the like, R 31 and R 32 each represent a hydrogen atom, C 1-6 alkyl, C 1-6 alkoxy, or the like, and W represents a single bond, the formula -NH-, the formula -O-, or the formula -CONH-, and Y represents a hydrogen atom or a structure represented by the following formula [3']:提供具有優異的NHE3阻礙作用之下述式〔1〕所表示之化合物或其製藥學所容許之鹽。【化15】A-Y [1](式〔1〕中，A為下述式〔2〕所表示之構造，在此，式〔2〕中，R11及R12為鹵素原子等，R2為C1-6烷基等，環E為三唑、四唑、嘧啶等，R31及R32為氫原子、C1-6烷基、C1-6烷氧基等，W為單鍵、式-NH-、式-O-、或式-CONH-，Y為氫原子或下述式〔3’〕所表示之構造。)
