A novel URAT1 inhibitor and a pharmaceutical application thereof. The inhibitor is a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, wherein a radical group of the compound is defined by the specification. The compound represented by formula (I) can be used to prepare a pharmaceutical product promoting uric acid excretion, specifically for preparing a pharmaceutical product for treating or preventing hyperuricemia or gout.本發明公開了一類新型URAT1抑制劑及其在醫藥上的應用，其為式(I)所示的化合物及其藥學上可接受的鹽，其中：Y或Z分別獨立地為N或CH，R1或R2分別獨立地選自H、D、鹵素、氰基、羥基、羧基、C1-4烷基、取代的C1-4烷基、C3-4環烷基、C1-4烷氧基、取代的C1-4烷氧基、苯基、取代的苯基、萘基、取代的萘基、雜芳基、取代的雜芳基中的一種或幾種，R3或R4分別獨立地選自H或C1-3烷基，或者R3和R4共同構成3-6元環烷基，R5為H、C1-4烷基、取代的C1-4烷基。本發明的化合物可應用於製備促尿酸排泄藥物，特別是治療或預防高尿酸血症或痛風藥物。
