This Hair Ming Department Off whats, which have, is subjected to Which Class on Qi Medical Drug of the pyrazole compound Huo of first type great Ma Alkaline (cannabinoid-1, CB1) antagonistic activity of Strong power, the Agencies of The compounds tool following formula [1] makes:[I]In formula,R1 With R2 are identical or different, and As Visual need the aryl etc. of The substitutionsR3 As alkyl etc.And E As following formula (i) is to formula (one of iv) Ji Mission persons:(i), (ii), (iii), (iv),Q1 As Single Key, alkyl or formula-N (R7)-Zhi Ji Mission are stretched, R7 As Hydrogen atoms or alkyl, Q2 As Single Key, oxygen atom stretch alkyl, R4 As Ring alkyl, formula-N (R5) (R6) Ji Mission etc., the one As Hydrogen atoms or alkyl and another one As alkyl of R5 With R6, the base Mission of formula-N (R8) (R9) etc., D As oxygen atoms etc., RA1 As amidos etc., RA2 As Visual need the Zhi Fang Zu Miscellaneous Ring bases of The substitutions, R As Visual need alkyl of mono- to three Ge Halogen element atom substitutions of The etc. and the one As Hydrogen atoms or alkyl and another one As alkyl etc. of R8 With R9.本發明係關於具強力之第一型大麻鹼(cannabinoid-1,CB1)拮抗活性之吡唑化合物或其醫藥上可接受之鹽類,該化合物具下式[1]之構造:[I]式中,R1與R2相同或不同,為視需要經取代之芳基等;R3為烷基等;以及E為下列式(i)至式(iv)基團中之一者:(i), (ii), (iii), (iv),Q1為單鍵、伸烷基或式-N(R7)-之基團,R7為氫原子或烷基,Q2為單鍵、氧原子或伸烷基,R4為環烷基、式-N(R5)(R6)之基團等,R5與R6之一者為氫原子或烷基且另一者為烷基、式-N(R8)(R9)之基團等,D為氧原子等,RA1為胺基等,RA2為視需要經取代之脂肪族雜環基,R為視需要經一至三個鹵素原子取代之烷基等,及R8與R9之一者為氫原子或烷基且另一者為烷基等。
