The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formulawhereinis phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl；is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions； R1is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen； n is 1 or 2； if n is 2, R1may be the same or not； R2/R2'are independently from each other lower alkyl, or form together with the carbon atom to which they are attached a C3-6-cycloalkyl ring； R3is lower alkyl, C3-6-cycloalkyl, CH2-C3-6-cycloalkyl, C3-6-cycloalkyl wherein one ring-carbon atom is replaced by -O-, (CH2)3-O-C3-6-cycloalkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, (CH2)3-S(O)2-C3-6-cycloalkyl or (CH2)2-S(O)2-lower alkyl； R4is hydrogen, halogen or lower alkyl； m is 1 or 2； if m is 2, R4may be the same or not； as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.本發明係關於下通式之2-氧代-2,3-二氫吲哚，其中係苯基或選自吡啶基、嘧啶基、咪唑基、異噁唑基或吡唑基之雜芳基；係苯基或吡啶基，其中該吡啶基中之N原子可位於所有空位置(free positions)上；R1係氫、低碳數烷基、經鹵素取代之低碳數烷基、低碳數烷氧基或鹵素；n係1或2；若n係2，則R1可相同或不同；R2/R2'彼此獨立地係低碳數烷基，或與其所連接之碳原子一起形成C3-6-環烷基環；R3係低碳數烷基、C3-6-環烷基、CH2-C3-6-環烷基、一個環碳原子經-O-替代之C3-6-環烷基、(CH2)3-O-C3-6-環烷基、經羥基取代之低碳數烷基、經鹵素取代之低碳數烷基、(CH2)3-S(O)2-C3-6-環烷基或(CH2)2-S(O)2-低碳數烷基；R4係氫、鹵素或低碳數烷基；m係1或2；若m係2，則R4可相同或不同；以及其醫藥上可接受之鹽、外消旋混合物，或其相應鏡像異構物及/或其光學異構物及/或立體異構物。
