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用於治療CNS疾病的2-氧代-2,3-二氫-吲哚類化合物
专利权人:
F. HOFFMANN LA ROCHE AG
发明人:
BRUNNER, DANIELA,MALBERG, JESSICA,SHANKAR, BAVANI G. G,KOLCZEWSKI, SABINE,LIMBERG, ANJA,PRINSSEN, ERIC,RIEMER, CLAUS,STOLL, THEODER,西奧多‧施托爾,達尼埃拉‧布倫納,杰西卡‧馬爾貝格,巴瓦尼‧,‧尚卡爾,薩賓‧克爾茨維斯基,安雅‧林貝格,埃里克‧普林森,克勞斯‧里默爾
申请号:
HK15107160.2
公开号:
HK1206721A
申请日:
2015.07.27
申请国别(地区):
HK
年份:
2016
代理人:
摘要:
The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula wherein is phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl; is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen; n is 1 or 2; if n is 2, R1 may be the same or not; R2/R2′ are independently from each other lower alkyl, or form together with the carbon atom to which they are attached a C3-6-cycloalkyl ring; R3 is lower alkyl, C3-6-cycloalkyl, CH2—C3-6-cycloalkyl, C3-6-cycloalkyl wherein one ring-carbon atom is replaced by —O—, (CH2)3—O—C3-6-cycloalkyl, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, (CH2)3—S(O)2—C3-6-cycloalkyl or (CH2)2—S(O)2-lower alkyl; R4 is hydrogen, halogen or lower alkyl; m is 1 or 2; if m is 2, R4 may be the same or not; as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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