A compound of the formula (I) ** Formula ** in which A1 is oxygen, carbonyl, -CH2O-, -CH2-, -CONR11- or is absent； R1 is hydrogen, alkyl, haloalkyl, cycloalkyl, phenyl, halophenyl, alkoxybenzyl, carboxy, morpholinyl, alkylmorpholinyl, dioxothiomorpholinyl, 2-oxo-6-aza-spiro- [3.3] heptanyl, piperidinyl, alkylpiperidinyl, hydroxypyrazinyl, piperipypylpyrazinylpipenylpiylpyrazinylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipethylpiperazylpipenylpiperazylpipethylpiperazylpipethylpipenylpipethylpipenylpipethylpipenylpipethylpipenylpipethylpipenylpipethylpipenylpipethylpipenylpipenyl , azetidinyl, haloazetidinyl, hydroxyazetidinyl, alkoxyazetidinyl, 8-oxo-3-aza-bicyclo [3.2.1] octanyl, hydroxypyridazinyl, halopyrrolidinyl, formyl, pyridinyl, halopyridinyl, tetrahydropyranyl or thiopyranyl； R2 is hydrogen； R3 and R4 are independently selected from hydrogen, alkyl and phenyl； or R3 and R4 together with the carbon atom to which they are attached form a cycloalkyl, alkylpiperidinyl or alkoxycarbonylpiperidinyl； or R2 and R3 together with the nitrogen atom and the carbon atom to which they are attached form a pyrrolidinyl； R5 is alkyl, cycloalkyl, cycloalkylalkyl, phenyl, substituted phenyl, benzyl, naphthyl, alkylpyridazinyl, pyridinyl, halopyridinyl, said substituted phenyl is a phenyl substituted by one or two substituents independently selected from alkyl, alkoxy, alkoxyalkoxy, halogen, haloalkoxy, haloalkoxy , phenyl, halophenyl, halophenyloxy, alkylsulfonylphenyl, aminosulfonylphenyl, pyridinyl, alkylpyridinyl, halopyridinyl, alkoxypyridinyl, haloalkylpyridinyl, alkylsulfonylpyridinyl, alkylthiazolyl, piperidinyl, halopyl-pyrolyl-1-pyrazyl-alkylpyl-pyrazyl-alkylpyl-pyrazyl-alkylpyl-pyrol-1-pyridyl-pyrazyl-1-pyridyl-1-pyrol-1-pyrol-1-pyridyl-1-pyridyl-1-pyridyl-1-1-pyridyl-1-yl-pyrol-1-pyrol-1-pyridyl-1-pyridyl-1-pyridyl-1-pyrol-1-1-pyridyl-1-1-pyridyl-1-1-pyridyl-1-1-1-1-1 grou
