ASTLES, PETER CHARLES,GUIDETTI, ROSSELLA,TIDWELL, MICHAEL WADE,HOLLINSHEAD, SEAN PATRICK
申请号：
PE2011001219
公开号：
PE20110999A1
申请日:
2009.12.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It refers to a pure formula derivativeR1 is h, F, Cl, C1-C2 tar, etc.； R2 is tetrahydrofuran, tetrahydropyridol, etc.； R3 is h, or combined with R4 to form a fusion pirolin-2-one； R4 is C1-C2, C1-C2 fluoropropyl sulfonyl, cyclopentyl propyl or trioxides； R5 is h, CH3 or CF3； n is 0 or 1； X1 and X3 are CFN, ch or Cr6； X2 is C1 or C6； or C6 is C1 or C6, carbon chloride or C3. - methyl-1-1-1 - (1-1 - (1-methyl-1-1-1 -) - o-furan-3-il-8 - (2-trifluoro-phenyl) - 9h Purina,There are others This is also a pharmaceutical composer. These compounds are enhancers of CB2 and can be used to treat painREFERIDA A UN DERIVADO DE PURINA DE FORMULA (I), DONDE R1 ES H, F, Cl, ALQUILO C1-C2, ENTRE OTROS； R2 ES TETRAHIDROFURANILO, TETRAHIDROPIRANILO, ENTRE OTROS； R3 ES H O EN COMBINACION CON R4 FORMA UNA PIRROLIN-2-ONA FUSIONADA； R4 ES ALQUILO C1-C2, FLUOROALQUILO C1-C2, CICLOPROPILO O COCH3； R5 ES H, CH3 O CF3； n ES 0 O 1； X1 Y X3 SON N, CH O CR6； X2 ES CH O CR6； R6 ES F, Cl, CF3, OCH3 U OCF3. SON COMPUESTOS PREFERIDOS: 8-(2-CLORO-PIRIDIN-3-IL)-2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TETRAHIDRO-FURAN-3-IL-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(TERTAHIDRO-PIRAN-4-IL)-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TERTAHIDRO-FURAN-3-IL-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, ENTRE OTROS. TAMBIEN ESTA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECPETOR CANABINOIDE CB2 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR
