Referring to a Heterocyclic Compound of formula (i), where a and B are n o W is n or CH, CH R3 and R4 are H or c1-c6 alkyl, R3 and R4 are together = OR = = = N or s, NH - R2 y and Z are Oh, alkoxyl C1 C6 - or or - C (= o), among others r1 is alkyl of C1 - C6 substituted with one or More groups RZ is alkyl R2 C1 - C6 or alkyd ILO C1 - C6 substituted.Preferred compounds are: 9,10 dihydro - 2.3 - Dimethoxy - 8.9 - methylenedioxy - 11 - [2 - (dimethylamino) ethyl] - - - - 12 5,6,11 triazacrisen Ona, 2,3 - Dimethoxy - 8.9 - methylenedioxy - 11 - (2 - (dimethylamino) ethyl] - - - - crisen triaza 5,6,11 11h - 12 - ona, 8.9 - dimethoxy 2,3 methylenedioxy - - - 5 - [2 - (n, n-dimethylamino) ethyl] - 5h dibenzo [C, h] - naftir Idina, among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Topoisomerases and are useful in the treatment of colon cancer, kidney cancer, Breast Cancer, cancer pulmonarh1299, among othersREFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE A Y B SON N O CH W ES N O CH R3 Y R4 SON H, ALQUILO C1-C6 O R3 Y R4 JUNTOS SON =O, =S, =NH O =N-R2 Y Y Z SON OH, ALCOXILO C1-C6, O, O-C(=O), ENTRE OTROS R1 ES ALQUILO C1-C6 SUSTITUIDO CON UNO O MAS GRUPOS Rz R2 ES ALQUILO C1-C6 O ALQUILO C1-C6 SUSTITUIDO. SON COMPUESTOS PREFERIDOS: 11,12-DIHIDRO-2,3-DIMETOXI-8,9-METILENDIOXI-11-[2-(DIMETILAMINO)ETIL]-5,6,11-TRIAZACRISEN-12-ONA, 2,3-DIMETOXI-8,9-METILENDIOXI-11-[(2-DIMETILAMINO)ETILO]-11H-5,6,11-TRIAZA-CRISEN-12-ONA, 8,9-DIMETOXI-2,3-METILENDIOXI-5-[2-(N,N-DIMETILAMINO)ETIL]-5H-DIBENZO[c,h]1,6-NAFTIRIDINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS TOPOISOMERASAS Y SON UTILES EN EL TRATAMIENTO DE CANCER DE COLON, CANCER RENAL, CANCER DE SENO, CANCER PULMONARH1299, ENTRE OTROS
