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Compound heterocyclic compounds containing nitroglycerin as inhibitor of the production of Japanese amide
专利权人:
EISAI RANDD MANAGEMENT CO.; LTD.
发明人:
KITAZAWA, NORITAKA,ITO, KOICHI,HASEGAWA, DAIJU,WATANABE, TORU,SHINMYO, DAISUKE,SATO, NOBUAKI,UEMURA, TOSHIYUKI
申请号:
PE2011001502
公开号:
PE20120172A1
申请日:
2010.02.24
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It's an abiotic formula compound,R1 and R2 are C1-C6, c3-c8 cyclopropyl, alquenilo C2-C6, Alcoy C1-C6, etc.; cycloa is an aromatic heterocycle composed of 5 members, which is combined with 5 to 14 non aromatic rings, and can replace C1-C6, alquenilo C2-C6, etc.; X1 is a separate link, a group of C1-C6 tar, a group of C1-C6 tar Vinileno, among others; ring B is a group of phenyl, pyridine, oxazol, furan, etc.; m is an integer of 0-3; n is an integer of 0-2; W is n or C is the preferred compound: (+) - 8 - (5-isopropyl-4-methyl-2-methyl) - 2 - [6-methyldiazol-1-il] piridin-2-il-5, 6, 7, 8-tetrahydro-1 [zoidin] 1,4,5,1,1,1,1,1,1,1,1,1,1,1,1,1,1, among others, triazole [1,5-a] pyridine. These compounds inhibit the production of beta amide and can be used in the treatment of Alzheimer's disease, Down's syndrome, dementia and ameluval's disease.REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO C1-C6, CICLOALQUILO C3-C8, ALQUENILO C2-C6, ALCOXI C1-C6, ENTRE OTROS; EL ANILLO A ES UN GRUPO HETEROCICLICLO AROMATICO DE 5 MIEMBROS FUSIONADO CON UN ANILLO NO AROMATICO DE 5 A 14 MIEMBROS, OPCIONALMENTE SUSTITUIDO ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; X1 ES UN ENLACE INDIVIDUAL, UN GRUPO ALQUILENO C1-C6, UN GRUPO VINILENO, ENTRE OTROS; EL ANILLO B ES UN GRUPO FENILO, PIRIDINA, OXAZOL, FURANO, ENTRE OTROS; m ES UN ENTERO DE 0 A 3; n ES UN ENTERO DE 0 A 2; W ES N O C. SON COMPUESTOS PREFERIDOS: (+)-8-(5-ISOPROPIL-4-METOXI-2-METILFENIL)-2-[6-METOXI-5-(4-METILIMIDAZOL-1-IL)PIRIDIN-2-IL-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, (-)-2-[5-METOXI-6-(4-METILIMIDAZOL-1-IL)PIRIDIN-3-IL]-8-(2-TRIFLUOROMETILFENIL)-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, (-)-8-(4-BROMO-2-TRIFLUOROMETILFENIL)-2-[6-METOXI-5-(4-METILIMIDAZOL-1-IL)PIRIDIN-2-IL]-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA PRODUCCION DE BETA-AMILOIDES Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, SINDROME DE DOWN, DE
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