GIBBONS, PAUL,HANAN, EMILY,LIU, WENDY,LYSSIKATOS, JOSEPH P.,MAGNUSON, STEVEN R.,MENDONCA, ROHAN,PASTOR, RICHARD,RAWSON, THOMAS E.,SIU, MICHAEL,ZAK, MARK E.,ZHOU, AIHE,ZHU, BING-YAN
申请号：
PE2012000003
公开号：
PE20120575A1
申请日:
2010.07.02
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
A compound made from a derivative of formula (I) pyrazolpyridin,WHERE R1 IS H, C1-C6-ALKYL, OR6, NR6R7 OR HALOGEN； R2 IS A HETEROARIL OF 5 OR 6 MEMBERS OPTIONALLY REPLACED WITH R4； R3 IS PHENYL, CYCLOALKYL C3-C6, HETEROCICLIL FROM 3 TO 10 MEMBERS, AMONG OTHERS； R4 IS C1-C6 ALKYL, C2-C6 ALKYNYL, C2-C6 ALKYNYL, AMONG OTHERS； R6 AND R7 ARE H, ALKYL C1-C6, ALKYNIL C2-C6, CN, AMONG OTHERS. THEY ARE PREFERRED COMPOUNDS: N- (3- (5-CHLORO-2-METOXIFENIL) -1-METHYL-1H-PIRAZOL-4-IL) PIRAZOLO [1,5-a] PIRIMIDINE-3-CARBOXAMIDE, N- (5- (5-CHLORO-2-METOXIFENIL) -1-METHYL-1H-PIRAZOL-4-IL) PIRAZOLO [1,5-a] PIRIMIDINA-3-CARBOXAMIDA, N- (3- (2,5-DIMETILOFENIL) -1 -METIL-1H-PIRAZOL-4-IL) PIRAZOLO [1,5-a] PYRIMIDINE-3-CARBOXAMIDE,There are others A pharmaceutical composer was also mentioned These compounds inhibit one or more quinine and can be used to treat cancer, polypeptide, bone marrow fibrosis, Crohn's disease, rheumatoid arthritis, thrombositis, etc.REFERIDA A UN COMPUESTO DERIVADO DE PIRAZOLOPIRIMIDINA DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C6, OR6, NR6R7 O HALOGENO； R2 ES UN HETEROARILO DE 5 O 6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON R4； R3 ES FENILO, CICLOALQUILO C3-C6, HETEROCICLILO DE 3 A 10 MIEMBROS, ENTRE OTROS； R4 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS； R6 Y R7 SON H, ALQUILO C1-C6, ALQUINILO C2-C6, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(3-(5-CLORO-2-METOXIFENIL)-1-METIL-1H-PIRAZOL-4-IL)PIRAZOLO[1,5-a]PIRIMIDINA-3-CARBOXAMIDA, N-(5-(5-CLORO-2-METOXIFENIL)-1-METIL-1H-PIRAZOL-4-IL)PIRAZOLO[1,5-a]PIRIMIDINA-3-CARBOXAMIDA, N-(3-(2,5-DIMETILOFENIL)-1-METIL-1H-PIRAZOL-4-IL)PIRAZOLO[1,5-a]PIRIMIDINA-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN UNA O MAS JANUS QUINASAS Y SON UTILES EN EL TRATAMIENTO DE CANCER, POLICITEMIA VERA, MIELOFIBROSIS, ENFERMEDAD DE CHRON, ARTRITIS REUMATOIDE, TROMBOCITOSIS PRIMARIA, ENTRE OTROS
