WANG, LE,PRATT, JOHN K.,MCDANIEL, KEITH F.,DAI, YUJIA,FIDANZE, STEVEN D.,HASVOLD, LISA,HOLMS, JAMES H.,KATI, WARREN M.,LIU, DACHUN,MANTEI, ROBERT A.,MCCLELLAN, WILLIAM J.,SHEPPARD, GEORGE S.,WADA, CAR
申请号：
PE0010492014
公开号：
PE23402014A1
申请日:
2012.12.11
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to a Heterocyclic Compound of formula (i), where RX is H, or C1 - C3 alkyl R is alkyl (alquenil C1 - C3, C2 or C3) - Oh haloalquilo x1 is n or crx1 RX1 is H, alquenilo C2 - C6, alquinilo C2 - C6, among others x2 is or crx2 crx2 is H, alquenilo C2 - C6, alquinilo C2 - C6, among others y1 is n or C Ru ru C1 - C6 is H, alkyl, halogen,Among others, A1 or A2 is CR1, CR2 and Cr3 ar is n or N A4 or CR4, R1, R3 and R4 are h, alkyl of C1 - C6, alquenilo C2 - C6, among others R2 is H, alkyl of C1 - C6, alquenilo C2 - C6, halogen, among others, L1 is CH2 C (or c), (H) (OH), among others G1 is c1-c6 alkyl, alkoxyalkyl esters, among others.Preferred compounds are: 4 - (5 - amino - 2 - fenoxifenil) - 6 - methyl - 4 - oxo - 6.7 - dihydro 1h pyrrolo [2,3-d] pyridazin-3 2 - carboxylate Ethyl 4 - [5 - (ethylamino) - 2 - fenoxifenil] - 6 - methyl - 7 - oxo - 6.7 - dihydro 1h pyrrolo [2,3-d] pyridazin-3 (2 - Ethyl carboxylate, among others. It also relates to a Pharmaceutical composition.These compounds have activity on the bromodominios and are useful in the treatment of inflammatory diseases, cancer, AIDS, etc.REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE Rx ES H O ALQUILO C1-C3 Ry ES ALQUILO C1-C3, (ALQUENIL C2-C3)-OH O HALOALQUILO X1 ES N O CRx1 Rx1 ES H, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS X2 ES N O CRx2 CRx2 ES H, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS Y1 ES N O CRu Ru ES H, ALQUILO C1-C6, HALOGENO, ENTRE OTROS A1 ES N O CR1 A2 ES N O CR2 AR ES N O CR3 A4 ES N O CR4 R1, R3 Y R4 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS R2 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, HALOGENO, ENTRE OTROS L1 ES CH2, C(O), C(H)(OH), ENTRE OTROS G1 ES ALQUILO C1-C6, ALCOXIALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(5-AMINO-2-FENOXIFENIL)-6-METIL-7-OXO-6,7-DIHIDRO-1H-PIRROLO[2,3-d]PIRIDAZIN-2-CARBOXILATO DE ETILO, 4-[5-(ETILAMINO)-2-FENOXIFENIL]-6-METIL-7-OXO-6,7-DIHIDRO-1H-PIRROLO[2,3-d]PIRIDAZIN-2-CARBOXILATO DE ETILO, ENTRE OTROS. TAMBIEN ESTA REF
