CHENG, HENGMIAO,JOHNSON, JR., THEODORE OTTO,KATH, JOHN CHARLES,LIU, KEVIN KUN-CHIN,LUNNEY, ELIZABETH ANN,NAGATA, ASAKO,NAIR, SAJIV KRISHNAN,PLANKEN, SIMON PAUL,SUTTON, SCOTT CHANNING
申请号：
PE0004032014
公开号：
PE12282014A1
申请日:
2012.09.10
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to pirrolopirimidina and purine derived compounds of formula (i), where X is n, and CR7 or, among others, Q, S, T, V and W are each independently, among others c, R1 and R4 are each independently h, cyano, difluorometilo, among others R2 and R3 are each independently Nte Hydrogen, C1 - C6 C1 - C6 alkyl, alkoxy alquinilo, C1 - C6,Among others, the ring is absent or is C3 - C10 heterocicloalquilo cycloalkyl, 3 - 10 members, among others and r5a R5 are each, independently, are absent or cyano, halogen, Hydroxy, among others R6 (ii), (iii) among others R7 is H, halogen, ciano, among others M is 0 - 2.Preferred compounds are {1 - (3R, 4R) - 3 - [({5-chloro-2 - [(1 - methyl - 1h-pyrazol-4-yl) amino] - 7h pyrrolo [2,3-d] pyrimidin-4-yl) oxy) methyl] - 4 - 1 - metoxipirrolidin - il} prop - 2 - in - 1 - ona n - [3 - [5 - (1 - methyl - 1h-pyrazol-4-yl) - 2 - [(1 - methyl - 1h-pyrazol-4-yl) amino] - 7h pyrrolo [2,3-d] pyrimidine - 4-yl) oxy) phenyl] - 2 - enamida ENT prop Re. It also relates to a Pharmaceutical composition that is useful in the treatment of cancer.SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLOPIRIMIDINA Y PURINA DE FORMULA (I), DONDE X ES N, CR7 Y O, S, ENTRE OTROS Q, T, V Y W SON CADA UNO INDEPENDIENTEMENTE C, N, ENTRE OTROS R1 Y R4 SON CADA UNO, INDEPENDIENTEMENTE H, CIANO, DIFLUOROMETILO, ENTRE OTROS R2 Y R3 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, C1-C6 ALQUILO, C1-C6 ALQUINILO, C1-C6 ALCOXI, ENTRE OTROS EL ANILLO A ESTA AUSENTE O ES C3-C10 CICLOALQUILO, HETEROCICLOALQUILO DE 3-10 MIEMBROS, ENTRE OTROS R5 Y R5a ESTAN CADA UNO, INDEPENDIENTEMENTE, AUSENTES O SON HALOGENOS, CIANO, HIDROXI, ENTRE OTROS R6 ES (II), (III) ENTRE OTROSR7 ES H, HALOGENO, CIANO, ENTRE OTROS m ES 0-2 . SON COMPUESTOS PREFERIDOS 1-{(3R,4R)-3-[({5-CLORO-2-[(1-METIL-1H-PIRAZOL-4-IL)AMINO]-7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL}OXI)METIL]-4-METOXIPIRROLIDIN-1-IL}PROP-2-EN-1-ONAN-[3-({5-(1-METIL-1H-PIRAZOL-4-IL)-2-[(1-METIL-1H-PIRAZOL-4-IL)AMINO]-7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL}OXI)FENIL
