APPUKUTTAN, PRASAD,GEORGE, SHYLA,UJJINAMATADA, RAVI KOTRABASAIAH,NARASINGAPURAM ARUMUGAN, KARTHIKEYAN,RAJAGOPALAN, SRINIVASAN,LINNANEN, TERO
申请号：
PE0021042015
公开号：
PE01152016A1
申请日:
2014.04.03
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The Invention relates to a compound of formula (i) useful in the treatment of cancer, where Z1 Z2 is n is CH or CH is Z1 and Z2 is n or Z1 and Z2 are n Z is CH or n phenyl Ring r1 is alkyl, etc. is C1 - C7 R2 is H, etc. Halogen Heterocyclic Ring B is, etc., etc. R3 is H, halogen, etc. R4 is H, Halog Eno is R5 H etc., etc.Preferred compounds are: 4 - (2,4-difluorophenyl) - N - (1 - methyl - 3 - 1H pyrazole - il) - 6 - (5 - (1 - methyl - 1h-pyrazol-4-yl) - 1H benzo [d] imidazol-1-yl) pyridin - 2 - Amine n - (4 - (2,4-difluorophenyl) - 6 - (5 - (1 - methyl - 1h-pyrazol-4-yl) - 1H benzo [d] imidazol-1-yl) pyridin-2-yl) ciclopropansulfonamidaSe describe un compuesto de la formula (I), util en el tratamiento del cancer donde Z1 es N Z2 es CH o Z1 es CH y Z2 es N o Z1 y Z2 son N Z es CH o N A es anillo fenilo, etc. R1 es alquilo C1-C7, etc. R2 es H, halogeno, etc. B es anillo heterociclico, etc. R3 es H, halogeno, etc. R4 es H, halogeno, etc. R5 es H etc. Los compuestos preferidos son: 4-(2,4-difluorofenil)-N-(1-metil-1H-pirazol-3-il)-6-(5-(1-metil-1H-pirazol-4-il)-1H-benzo[d]imidazol-1-il)piridin-2-amina N-(4-(2,4-difluorofenil)-6-(5-(1-metil-1H-pirazol-4-il)-1H-benzo[d]imidazol-1-il)piridin-2-il)ciclopropansulfonamida
