MCIVER, EDWARD GILES,SMILJANIC, ELA,HARDING, DENISE JAMILLA,HOUGH, JOANNE
申请号：
PE0016622011
公开号：
PE05062012A1
申请日:
2010.03.19
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a pirazolopiridina Derivative of formula (i), wherein R1 is heterocicloalquilo c4-c7, nhr3, OR3, Oh, among others R2 is H, c1-c6 alkyl, cycloalkyl alquenilo C2 - C3 - C7, C6, among others R3 is heterocicloalquilo C4 C3 - C7 C7, cycloalkyl, aryl, among others.Preferred compounds are: (4 - Chloro - (benzyl) - 3 - methyl - 4.3 - 1H pyrazolo [c] pyridin-4-yl) - (Cyclohexyl Amine - 3 - methyl - 4.3 - 1H pyrazolo [c] pyridin-4-yl) - 3 - methyl amine (- 1H 4.3 - pyrazolo [c] pyridin-4-yl) - (1 - Methyl - 3 - 1H pyrazole Amine - il), among others. It also relates to a Pharmaceutical Composition and a Preparation Process.These compounds inhibit one or more Kinases, particularly, LRRK2 and are useful in the treatment of cancer, Neurodegenerative Diseases, among othersREFERIDA A UN DERIVADO DE PIRAZOLOPIRIDINA DE FORMULA (I), DONDE R1 ES HETEROCICLOALQUILO C4-C7, NHR3, OR3, OH, ENTRE OTROS R2 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C7, ENTRE OTROS R3 ES HETEROCICLOALQUILO C4-C7, CICLOALQUILO C3-C7, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (4-CLORO-BENCIL)-(3-METIL-1H-PIRAZOLO[4,3-c]PIRIDIN-4-IL)-AMINA, CICLOHEXIL-(3-METIL-1H-PIRAZOLO[4,3-c]PIRIDIN-4-IL)-AMINA, (3-METIL-1H-PIRAZOLO[4,3-c]PIRIDIN-4-IL)-(1-METIL-1H-PIRAZOL-3-IL)-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS INHIBEN UNA O MAS QUINASAS, PARTICULARMENTE, LRRK2 Y SON UTILES EN EL TRATAMIENTO DE DEL CANCER, ENFERMEDADES NEURODEGENERATIVAS, ENTRE OTROS
