COOKE, NIGEL GRAHAM,FERNANDES GOMES DOS SANTOS, PAULO,GRAVELEAU, NADEGE,HEBACH, CHRISTINA,HOGENAUER, KLEMENS,HOLLINGWORTH, GREGORY JOHN,SMITH, ALEXANDER BAXTER,SOLDERMANN, NICOLAS,STOWASSER, FRANK,STR
申请号：
PE2013000017
公开号：
PE20130650A1
申请日:
2011.07.06
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
The invention relates to a tetrahydropyridin derivative of formula (I),Where y is nr3u； R1 is phenyl, pyridine, pyridyl, pyridyl, pyridyl, etc.； R2 is phenyl, naphthalene, pyridyl, etc.； R3 is h, C1-C4 tar or C1-C4 halogen tar； m is 0 or 1. Pir4-4]]] - [pir4-4-4]]]] - [pir4 - [3-4 - [3]]]] - (d) pyridine-6-il} - nicotine, 5 - {3 - [6 - (6-methyl-5-methyl-pyridine-3-il) - 5, 6, 7，8-Terahiro-Pirido-[4，3-d]Pirimidin-4-Iloxi]-Pirrolidin-1-carbonil}-1H-Piridin-2-ona，There are others A drug synthesis and preparation procedure was also mentioned. These compounds are inhibitors of phosphoric acid 3 '- oh-cinasa (PI3K), which can be used to treat autoimmune diseases, inflammation, allergies, respiratory tract infections, cancer, etc.REFERIDA A UN DERIVADO DE TETRAHIDRO-PIRIDO-PIRIMIDINA DE FORMULA (I), DONDE Y ES NR3 U O； R1 ES FENILO, PIRIDILO, PIRIMIDINILO, PIRAZINILO, ENTRE OTROS； R2 ES FENILO, NAFTILO, PIRIDILO, PIRIMIDINILO, ENTRE OTROS； R3 ES H, ALQUILO C1-C4 O HALOALQUILO C1-C4； m ES 0 O 1. SON COMPUESTOS PREFERIDOS: {(S)-3-[6-(6-METOXI-5-METIL-PIRIDIN-3-IL)-5,6,7,8-TETRAHIDRO-PIRIDO-[4,3-d]-PIRIMIDIN-4-ILOXI]-PIRROLIDIN-1-IL}-(TETRAHIDRO-PIRAN-4-IL)-METANONA, 2-METOXI-5-{4-[(S)-1-(TETRAHIDRO-PIRAN-4-CARBONIL)-PIRROLIDIN-3-ILOXI]-7,8-DIHIDRO-5H-PIRIDO[4,3-d]PIRIMIDIN-6-IL}-NICOTINONITRILO, 5-{3-[6-(6-METOXI-5-METIL-PIRIDIN-3-IL)-5,6,7,8-TERAHIDRO-PIRIDO-[4,3-d]PIRIMIDIN-4-ILOXI]-PIRROLIDIN-1-CARBONIL}-1H-PIRIDIN-2-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA 3'-OH-CINASA DE FOSFOINOSITIDA (PI3K) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, INFLAMATORIAS, ALERGICAS, DE LAS VIAS RESPIRATORIAS, CANCER, ENTRE OTRAS
