ZHANG, XUQING,HUFNAGEL, HEATHER RAE,HOU, CUIFEN,JOHNSON, DANA L.,SUI, ZHIHUA,FEGELY, BARRY,BRESLIN, DAVID
申请号：
PE2011001208
公开号：
PE20110928A1
申请日:
2009.12.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
A formula (I) cyclohexane compound,Among them, R1 is pyridine, pyridine-n-oxidation, indolilo, etc.； R2 is C1-C4, NH2, NO2, etc.； R3 is h, F, CF3, etc.； R4 is h, or C1-C4, F. is the preferred compound: n - ({1 - [4-hydroxi-4 - (6-methylpiridin-3-il) - cyclohexane] - azetidin-3-ilcarbamoil-methyltrifluoro-trifluoro-trifluoro-3 N - ({1 - [4-hydroxi-4 - (6-methoxi-1-oxi-piridin-3-il) - cyclohexyl] - azetidin-3-ilarbamoil} - methyl) - 3-trifluorometl-benzamida, N - ({1 - [4 - (6-etoxi-piridin-3-hydrohexyl) - 4-3-ilarbamoil} - methyl) - 3-trifluoromethyl-benida,There are others A pharmaceutical composer was also mentioned These compounds are antagonistic to the recipients of cytochemical inhibitor 2 (CCR2), and can be used to treat chronic obstructive pulmonary disease, juvenile disease, rheumatoid arthritis, etc.REFERIDA A UN COMPUESTO CICLOHEXANOL DE FORMULA (I), DONDE R1 ES PIRIDILO, PIRIDIL-N-OXIDO, INDOLILO, ENTRE OTROS； R2 ES ALQUILO C1-C4, NH2, NO2, ENTRE OTROS； R3 ES H, F, CF3, ENTRE OTROS； R4 ES H, O-ALQUILO C1-C4, F. SON COMPUESTOS PREFERIDOS: N-({1-[4-HIDROXI-4-(6-METOXI-PIRIDIN-3-IL)-CICLOHEXIL]-AZETIDIN-3-ILCARBAMOIL}-METIL)-3-TRIFLUOROMETIL-BENZAMIDA, N-({1-[4-HIDROXI-4-(6-METOXI-1-OXI-PIRIDIN-3-IL)-CICLOHEXIL]-AZETIDIN-3-ILCARBAMOIL}-METIL)-3-TRIFLUOROMETIL-BENZAMIDA, N-({1-[4-(6-ETOXI-PIRIDIN-3-IL)-4-HIDROXI-CICLOHEXIL]-AZETIDIN-3-ILCARBAMOIL}-METIL)-3-TRIFLUOROMETIL-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR 2 DE CITOCINA QUIMIOATRAYENTE (CCR2) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES OBSTRUCTIVAS CRONICAS PULMONARES, UVEITIS, ARTRITIS REUMATOIDE, ENTRE OTRAS
